Ex parte ROSENBLUM et al. - Page 17




              Appeal No. 1997-3542                                                                                       
              Application No. 08/192,507                                                                                 


              deficiencies of the primary references.  In view of the above, the rejection of claims 3, 4,               
              14 and 15 under 35 U.S.C. § 103  is reversed.                                                              
              35 U.S.C. § 103                                                                                            
                     Claims 5 and 13 stand rejected under 35 U.S.C. § 103 over Julius and Kung, taken                    
              with Lambert and Taylor, as applied to claims 1, 2, 5-7, 11-13, 16 and 17, and further in                  
              view of Brady.                                                                                             
                     The examiner relies on Brady for the teaching of the production of radionucleotides                 
              for use in diagnostic imaging.  The examiner argues that it would have been obvious to                     
              one of ordinary skill in the art at the time of the present invention to produce immunotoxins              
                                       131                                                                               
              containing radiolabelled I as the cytotoxic agent moiety in view of the demonstrated use                   
                131                                                                                                      
              of I for this purpose.                                                                                     
                     Having found the primary combination of references to be without proper                             
              motivation and that Brady does not cure the deficiencies of the primary references, the                    
              rejection of claims 5 and 13 under 35 U.S.C. § 103  is reversed.                                           
              Other Issue                                                                                                
                     We also note that the oath or declaration filed in the application remains defective,               
              as set forth in Paper No. 2, page 3.   Should prosecution of the subject                                   






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