Ex parte MILLER et al. - Page 6


                  Appeal No. 1998-3386                                                                                        
                  Application No. 08/265,698                                                                                  
                  prior art to produce the claimed invention where there is some teaching, suggestion,                        
                  or motivation to do so found either in the references themselves or in the knowledge                        
                  generally available to one of ordinary skill in the art.  See In re Fine, 837 F.2d 1071,                    
                  1075, 5 USPQ2d 1596, 1598 (Fed. Cir. 1988).  On this record we find no                                      
                  suggestion to modify Lackner, to apply pressure to said reaction mixture, as would                          
                  be necessary to arrive at the claimed invention.                                                            
                         The examiner suggests (Answer, page 5) that “pressure” is a result effective                         
                  variable and therefore “optimization of result effective processes [sic] parameters is                      
                  well within the skill of those in the art.”  However, this determination requires that                      
                  “pressure” be recognized as a result effective variable in this system.  In re Antonie,                     
                  559 F.2d 618, 620, 195 USPQ 6, 9 (CCPA 1977).  Applying pressure is not                                     
                  suggested by the teachings of Lackner.  Lackner made no attempt to apply                                    
                  pressure, but instead, as discussed supra, recognized that “[d]ue to diffusion                              
                  limitation, a slower degradation rate than without dialysis tubing was observed.”                           
                  Lackner does not reveal the concept of applying pressure that appellant discovered,                         
                  and the examiner has provided us with no other basis to find the claimed invention                          
                  obviousness.                                                                                                
                         Therefore, on this record we are compelled to find that the examiner failed to                       
                  meet his burden of establishing a prima facie case of obviousness.  Where the                               
                  examiner fails to establish a prima facie case, the rejection is improper and will be                       
                  overturned.  In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598 (Fed. Cir.                                
                  1988).                                                                                                      



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