Appeal No. 1999-2200 Application No. 08/896,063 Claim 31: We note the examiner’s statement (Answer, page 8) that “[t]he disclosure of the sequence of human GluR4B as amino acids 1-881 of SEQ ID NO:2 is the recitation of an inherent property of a protein that was known to exist and does not make that compound unobvious.” In response, appellants cite (Reply Brief71, page 1) In re Spormann, 363 F.2d 444, 448, 150 USPQ 449, 452 (CCPA 1966) for the position that “[t]hat which may be inherent is not necessarily known …. Obviousness cannot be predicated on what is unknown.” We agree. There is no suggestion or reasonable expectation in the combination of prior art relied upon by the examiner that a GluR4B comprising amino acid residues 1- 881 of SEQ-ID NO:2 would have been obtained. Therefore, in our opinion, the examiner failed to meet her burden of establishing a prima facie case of obviousness. Where the examiner fails to establish a prima facie case, the rejection is improper and will be overturned. In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598 (Fed. Cir. 1988). Accordingly, we reverse the rejection of claim 31 under 35 U.S.C. § 103 over the combination of McNamara and Sommer. Summary: We affirm the rejection of claims 17 and 19 under 35 U.S.C. § 103 as being unpatentable over the combination of McNamara and Sommer ‘90. 97Page: Previous 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 NextLast modified: November 3, 2007