Appeal No. 2000-0018 Application No. 08/860,941 teachings of Watson and Kasturi or the combined teachings of these references further with Chapple, such that it is in liquid form and has a pH in the 6.5-12 range. Kasturi discloses that his detergent composition can be in liquid form (col. 24, line 66; col. 25, line 20) and that the treatment solution pH is preferably 7 to 11, especially 7.5 to 10.5 (col. 20, lines 50-51). For this reason and that given above regarding claim 1, Kasturi would have fairly suggested the composition recited in the appellants’ claim 15 to one of ordinary skill in the art. The appellants argue that Watson’s pH is that of the wash water rather than the detergent (brief, page 7; reply brief, page 4). It reasonably appears, however, that one of ordinary skill in the art would have expected a desired wash water pH to be obtained by use of a detergent having that pH rather than another pH. The appellants have provided no evidence or reasoning to the contrary. The appellants argue that Watson discloses a pH optimum of 5 to 9.5 for bacterial and fungal cellulase, but does not disclose a pH optimum for amalyse (reply brief, page 4). For a prima facie case of obviousness to be established, however, 9–Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 NextLast modified: November 3, 2007