Ex parte BROWN et al. - Page 9




          Appeal No. 2000-0018                                                        
          Application No. 08/860,941                                                  


          teachings of Watson and Kasturi or the combined teachings of                
          these references further with Chapple, such that it is in                   
          liquid form and has a pH in the 6.5-12 range.                               
               Kasturi discloses that his detergent composition can be                
          in liquid form (col. 24, line 66; col. 25, line 20) and that                
          the treatment solution pH is preferably 7 to 11, especially                 
          7.5 to 10.5 (col. 20, lines 50-51).  For this reason and that               
          given above regarding claim 1, Kasturi would have fairly                    
          suggested the composition recited in the appellants’ claim 15               
          to one of ordinary skill in the art.                                        
               The appellants argue that Watson’s pH is that of the wash              
          water rather than the detergent (brief, page 7; reply brief,                
          page 4).  It reasonably appears, however, that one of ordinary              
          skill in the art would have expected a desired wash water pH                
          to be obtained by use of a detergent having that pH rather                  
          than another pH.  The appellants have provided no evidence or               
          reasoning to the contrary.                                                  
               The appellants argue that Watson discloses a pH optimum                
          of 5 to 9.5 for bacterial and fungal cellulase, but does not                
          disclose a pH optimum for amalyse (reply brief, page 4).  For               
          a prima facie case of obviousness to be established, however,               
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