Ex parte BROWN - Page 2




              Appeal No. 2000-0643                                                                                        
              Application 08/273,423                                                                                      
                     This is an appeal under 35 U.S.C. § 134 from the final rejection of claims            1              
              through 16, all the claims in the application.  Claims 1 and 15 are representative and read                 
              as follows:                                                                                                 
                     1.  A composition for the treatment of hair loss comprising effective amounts of:                    
                            a corticosteroid,                                                                             
                            a Vitamin A derivative, and                                                                   
                            a carrier agent for said corticosteroid and said Vitamin A derivative.                        
                     15.  A method of treatment for hair restoration of a patient comprising the steps                    
                     of:                                                                                                  
                            administering a corticosteroid to a hairless area of the skin of the                          
                            patient; and                                                                                  
                            administering a Vitamin A derivative to said hairless area of the                             
                            skin of the patient.                                                                          
                     The references relied on by the examiner are:                                                        
              Kligman                             5,026,691                           Jun. 25, 1991                       

              Lesnik et al. (Lesnik), “Topical all-trans-retinoic acid prevents corticosteroid-induced skin               
              atrophy without abrogating the anti-inflammatory effect,” J. Am. Acad. Dermatol., Vol. 21,                  
              pp. 186-190 (1989)                                                                                          
              Bazzano et al. (Bazzano), “Effect of Retinoids on Follicular Cells,” J. Invest. Dermatol., Vol.             
              101, pp. 138S-142S (1993)                                                                                   
                     The claims stand rejected as follows:2                                                               
                     I.  Claims 1 through 9 under 35 U.S.C. § 103 as unpatentable over Lesnik.                            




                     2 According to the Advisory Action (paper no. 16, mailed April 16, 1997), the                        
              rejection of claims 1 through 16 under the first paragraph of 35 U.S.C. § 112 (as based on                  
              a non-enabling disclosure), and the rejection of claims 15 and 16 under the second                          
              paragraph of 35 U.S.C. § 112 have been withdrawn.                                                           
                                                            2                                                             





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