Appeal No. 2000-1812
Application No. 08/432,483
2. The isolated antigenic hybrid peptide according to claim 1 wherein the
helper T cell epitope portion is selected from the group consisting of a helper T cell
epitope amino acid sequence of tetanus toxoid, diphtheria toxoid, pertussis vaccine,
Bacile Calmette-Guerin (BCG), polio vaccine, measles vaccine, mumps vaccine, rubella
vaccine, purified protein derivative of tuberculin, keyhole limpet hemocyanin, and
combinations thereof.
5. An isolated antigenic hybrid peptide comprising the amino acid sequence of
SEQ ID NO: 2.
11. A method of elevating the ratio of circulating High Density Lipoprotein to
circulating Low Density Lipoprotein, Very Low Density Lipoprotein, or total cholesterol in a
human or other animal comprising administering to the human or animal an antigenic
vaccine hybrid peptide comprising a universal helper T cell epitope portion and a B cell
epitope portion, wherein said B cell epitope portion comprises six to 26 consecutive
amino acids of the carboxyl terminal 26 amino acids of human cholesteryl ester transfer
protein (SEQ ID NO: 1).
The references relied upon by the examiner are:
Weiner et al. (Weiner) 5,338,829 Aug. 16, 1994
Whitlock et al. (Whitlock), “Monoclonal antibody Inhibition of Cholesteryl Ester Transfer
Protein Activity in the Rabbit,” J. Clin. Invest., Vol. 84, pp. 129-137 (1989)
Swenson et al. (Swenson), “Mechanism of Cholesteryl Ester transfer Protein Inhibition by a
Neutralizing Monoclonal Antibody and Mapping of the Monoclonal Antibody Epitope,”
Journal of Biological Chemistry, Vol. 264, No. 24, pp. 14318-14326 (1989)
Valmori et al. (Valmori), “Use of human universally antigenic tetanus toxin T cell eptiopes
as carriers for human vaccination,” Journal of Immunology, Vol. 149, No. 2, pp. 717-721
(1992)
The following reference is relied upon by the Appellant:
Michel et al. (Michel), "Immunologic Approaches to Blockade of the renin-angiotensin
system: A review," American Heart Journal, Vol. 117 (3), pp 756-767 (1989)
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