Ex parte MOHR et al. - Page 6



                  Appeal No. 2001-0400                                                                                      
                  Application No. 08/751,624                                                                                

                  on page 6.  In fact, Heinmets discloses that methylene blue, azure blue II,                               
                  toluidine blue O, azure A, and azure B eliminated infectious virus upon                                   
                  irradiation,3 while thionine, aniline blue, and azure C reduced but did not                               
                  eliminate infectivity.  See id.                                                                           
                         All of these sources of evidence support enablement by showing that                                
                  minimal experimentation would be required to practice the claimed method with                             
                  many, if not most, phenothiazine dyes.  The examiner has provided no evidence                             
                  to rebut the evidence favoring enablement.  We conclude that the examiner’s                               
                  position is not supported by a preponderance of the evidence in the record and                            
                  therefore reverse the rejection for non-enablement.                                                       
                  2.  The obviousness rejection based on Heinmets                                                           
                         The examiner rejected claims 1-15, 19-22, 24, and 27 under 35 U.S.C.                               
                  § 103 as obvious in view of Heinmets.  The examiner notes that Heinmets                                   
                  teaches inactivation of viruses in plasma using a combination of phenothiazine                            
                  dye and irradiation.  The examiner acknowledges that “the claims include the                              
                  limitation of the concentration of dye is 0.5 – 2 micromolar whereas Heinmets                             
                  teaches a concentration down to 10 micromolar for the same function in Table 1                            
                  and down to 0.5 micromolar in Table 3.”  Examiner’s Answer, page 5.  The                                  
                  examiner concludes that                                                                                   
                         [i]t would have been obvious to one of ordinary skill in the art a t the                           
                         time the invention was made to employ the same dyes as Heinmets                                    
                         for the same function at a selected low concentration because                                      
                                                                                                                            
                  3 To be accurate, the Heinmets data show only that the treated plasma, when injected into mice,           
                  did not kill any of the mice.  The actual number of infectious viral particles was not quantified.        

                                                             6                                                              



Page:  Previous  1  2  3  4  5  6  7  8  9  10  11  12  13  Next 

Last modified: November 3, 2007