Ex parte MOHR et al. - Page 9



                  Appeal No. 2001-0400                                                                                      
                  Application No. 08/751,624                                                                                

                         The examiner noted that Heinmets teaches removal of a phenothiazine                                
                  dye (toluidine blue) from blood using an ion exchange resin, but does not teach                           
                  removal of such dyes using the claim-recited adsorbents.  The examiner relies on                          
                  either of Sugiyama or Hodgson to remedy this deficiency.  The examiner reasons                            
                  as follows:                                                                                               
                         Sugiyama . . . teaches in the claims a method for removing soluble                                 
                         poisonous substances from blood by bringing the blood into contact                                 
                         with an absorbent which in claim 4 is activated carbon.  In column 2                               
                         lines 40-48, the adsorbents may be porous resins, porous alumina,                                  
                         porous glass or ion exchange resins, selected depending upon the                                   
                         substances which are to be removed from blood by absorption.                                       
                         Hodgson . . . teaches a column for purifying blood, in column 2                                    
                         lines 35-42, the column may be filled with granules having activated                               
                         carbon or polystyrene granules.  In column 2 lines 55-60, other                                    
                         polymers are shown.  In column 4 line 6, any known particulate                                     
                         absorbent may be used.                                                                             
                         It would have been obvious to one of ordinary skill in the art at the                              
                         time the invention was made to employ the macroporous polymeric                                    
                         beads of either Sugiyama or Hodgson in the method of Heinmets to                                   
                         remove selected substances from blood because Sugiyama and                                         
                         Hodgson show such porous polymers are compatible with blood                                        
                         and effectively remove selected substances.                                                        
                  Examiner’s Answer, page 7.                                                                                
                         “The PTO has the burden under section 103 to establish a prima facie                               
                  case of obviousness.  It can satisfy this burden only by showing some objective                           
                  teaching in the prior art or that knowledge generally available to one of ordinary                        
                  skill in the art would lead that individual to combine the relevant teachings of the                      
                  references.”  In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598 (Fed. Cir.                             
                  1988) (citations omitted).  “The consistent criterion for determination of                                


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