Ex Parte KUFE et al - Page 3


                Appeal No. 2001-0690                                                                               
                Application No. 08/309,315                                                                         

                DISCUSSION                                                                                         
                       In reaching our decision in this appeal, we considered appellants’                          
                specification and claims, in addition to the respective positions articulated by the               
                appellants and the examiner.  We make reference to the examiner’s Answer4 for                      
                the examiner’s reasoning in support of the rejections.  We further reference                       
                appellants’ Brief5 for the appellants’ arguments in favor of patentability.                        
                THE REJECTION UNDER 35 U.S.C. § 103:                                                               
                Margolis in view of Akinaga                                                                        
                       The examiner refers (Answer, page 4) our attention to the statement of                      
                the rejection set forth in the Final Rejection6.                                                   
                       We initially note that in contrast to the examiner’s position (Final                        
                Rejection, page 3) appellants do not concede (See Brief, pages 10-11) that the                     
                use of a tyrosine kinase inhibitor is not critical since the protein kinase inhibitor              
                may be a serine/threonine kinase inhibitor or a tyrosine protein kinase inhibitor.                 
                Instead, appellants maintain (Brief, bridging sentence, pages 10-11) “there is no                  










                                                                                                                   
                4 Paper No. 25, mailed December 23, 1997.                                                          
                5 Paper No. 24, received September 15, 1997.                                                       
                6 Paper No. 18, mailed December 18, 1996.                                                          

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