Ex parte VOORDOUW et al. - Page 6


                     Appeal No. 1995-3965                                                                                                         
                     Application No. 07/719,005                                                                                                   

                     hybridization.”  Therefore, appellants conclude (Answer, page 17) that “[w]hen                                               
                     considering the above-described fundamental difference as a whole, it is crucial to                                          
                     note that Kimmel provides absolutely no suggestion of any technique which would                                              
                     enable the detection of more than one microorganism using a single                                                           
                     incubation/hybridization.”                                                                                                   
                              In response the examiner argues (Answer, pages 8 and 9) that appellants                                             
                     admit, “in Paper 16, filed May 10, 1993 ‘that the laboratory procedures required to                                          
                     carry out the reverse hybridization technique are well known and are fully disclosed                                         
                     in Wang et al.’”  We are not persuaded by this argument.  While “laboratory                                                  
                     procedures” (e.g., Southern Blot procedures) may be well known, it is the claimed                                            
                     invention as a whole that must be considered in an obviousness determination.                                                
                     See In re Antonie, 559 F.2d 618, 625, 195 USPQ 6, 8 (CCPA 1977).  Furthermore,                                               
                     as set forth in In re Nomiya, 509 F.2d 566, 571, 184 USPQ 607, 612 (CCPA 1975)                                               
                     “[t]he court must be ever alert not to read obviousness into an invention on the basis                                       
                     of the applicant’s own statements; that is, we must view the prior art without reading                                       
                     into that art appellant’s teachings.”                                                                                        
                              The examiner also argues (Answer, pages 9-10) that “Kimmel explicitly                                               
                     teaches the same principle as found in this application, namely, that one could mix                                          
                     probes of different DNA species and use this probe mixture to simultaneously                                                 
                     detect complementary DNA of several different species by hybridizing to multiple                                             
                     spots … with a single hybridization….”  Thus the examiner concludes (Answer,                                                 
                     bridging sentence, pages 10-11), “[t]aken together with the Wang et al. procedure,                                           


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