Ex parte CALABRESI et al. - Page 4




              Appeal No. 1996-3866                                                                                     
              Application 08/087,957                                                                                   


                     According to the examiner, Minor teaches “the combination of AZT (zidovudine) and                 
              methotrexate for treating cancer (Kaposi's Sarcoma) in patients.”   Answer, page 3.  The                 
              examiner also finds that “the reference clearly shows that while four patients were on                   
              zidovudine (AZT) they received chemotherapy, methotrexate.   In view of this, one of                     
              ordinary skill in the art would be motivated to administer AZT with methotrexate to treat                
              cancer.   The specific cancers being treated are clearly within the skill of the art.”  Id.              
                     The manner in which the examiner has put forth the statement of rejection has made                
              it difficult for us to clearly determine what the examiner considers to be obvious.   For                
              example, in reading the statement rejection, the examiner has indicated that “one skilled in             
              the art would be motivated to administer AZT with methotrexate to treat cancer.”   Answer,               
              page 3.   The examiner has never explained why, in view of such motivation, one skilled in               
              the art would consider the claimed subject matter as a whole to have been obvious.                       
                     As set forth in the Manual of Patent Examining Procedure (MPEP) § 706.02(j) (6th                  
              ed., no. 3, July 1997),                                                                                  
                     the examiner should set forth . . .  (1) the relevant teachings of the prior art                  
                     relied upon, preferably with reference to the relevant column or page                             
                     number(s) and line number(s) where appropriate, (2) the difference or differ-                     
                     ences in the claim over the applied reference(s), (3) the proposed                                
                     modification of the applied reference(s) necessary to arrive at the claimed                       
                     subject matter, and (4) an explanation why such proposed modification                             
                     would have been obvious to one of ordinary skill in the art at the time the                       
                     invention was made.                                                                               



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