Ex parte BRYANT et al. - Page 3




                Appeal No. 1997-1955                                                                                                           
                Application No. 08/423,498                                                                                                     
                resulting in a wide range of symptoms.  There are various approaches to treating                                               
                endometriosis, including administration of estrogens, progestins or weak androgens, but,                                       
                according to the specification, “treatment by hormonal therapy is diverse, poorly defined,                                     
                and marked by numerous unwanted . . . side effects.”  Page 5.                                                                  
                                                              DISCUSSION                                                                       
                         Claims 46 through 51 on appeal are directed to a method of inhibiting                                                 
                endometriosis by administering an effective amount of a benzothiophene of formula I (see                                       
                the Appendix accompanying appellants’ Brief).  Claim 36 of co-pending application serial                                       
                no. 08/438,334 is also directed to a method of inhibiting endometriosis, but the base ring                                     
                structure of the compound administered is a benzofuran, rather than a benzothiophene.  A                                       
                comparison of the formulas of the compounds administered in the methods of the present                                         
                and co-pending applications shows that the only difference between them is in the base                                         
                ring structure: position 1 of the benzothiophenes is sulfur, while position 1 of the                                           
                benzofurans is oxygen.                                                                                                         
                         In the Examiner’s Answer, the examiner refers to paper nos. 5 and 7 for the                                           
                statement of the rejection, although the rejection appears only in paper no. 5.  In view of its                                
                brevity, we reproduce the rejection in its entirety:                                                                           
                         The instant application claims the use of a benzothienyl compound for                                                 
                         treating endometriosis while SN 08/438,334 claims the same method using                                               
                         a prima facie obvious compound i.e. a benzofuranyl compound as                                                        
                         recognized in the prior art as equivalence of the instant claim (see Crenshaw                                         
                         and Erber).  One having ordinary skill in the art would recognized all the                                            


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