Ex parte REYNOLDS - Page 4




              Appeal No. 1997-2364                                                                                             
              Application 08/137,086                                                                                           
              phosphopeptide aggregates.”  “[I]n order to maintain the integrity of the anticariogenic                         
              phosphopeptide aggregates,” and “allow[] separation of the anticariogenic from the non-                          
              anticariogenic phosphopeptides,” “[t]he addition of a CaCl  solution, or some other                              
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              suitable di/trivalent metal ion . . . is essential” during diafiltration, and the “molecular weight              
              exclusion limit of the membrane filter should not be less than 10,000 or greater than about                      
              20,000.”  Specification, pages 1, 3 and 4.                                                                       
              Rejection I                                                                                                      
                      Claims 1 through 6, 8 through 14, 17 and 18 are directed to a process of preparing                       
              selected phosphopeptides, and to products of that process.  The claims stand rejected as                         
              anticipated by, or in the alternative, as obvious over Brule.                                                    
                      It is well settled that the initial burden of establishing unpatentability rests on the                  
              examiner, In re Oetiker, 977 F.2d 1443, 1446, 24 USPQ2d 1443, 1445 (Fed. Cir. 1992).                             
              That being said, we recognize that there are exceptions where the record justifies shifting                      
              the burden to appellant to show a difference between the claimed invention and the prior                         
              art.  As explained in In re Best, 562 F.2d 1252, 1255, 195 USPQ 430, 433-34 (CCPA                                
              1977):                                                                                                           
                      Where . . . the claimed and prior art products are identical or substantially                            
                      identical, or are produced by identical or substantially identical processes,                            
                      the PTO can require an applicant to prove that the prior art products do not                             
                      necessarily or inherently possess the characteristics of his claimed product .                           
                      . . . Whether the rejection is based on ‘inherency’ under 35 U.S.C. § 102, on                            
                      ‘prima facie obviousness under 35 U.S.C. § 103, jointly or alternatively, the                            
                      burden of proof is the same, and its fairness is evidenced by the PTO’s                                  


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