Appeal No. 1997-2517
Application No. 08/155,102
Matzuk et al (Matzuk JCB), “Secretion Studies of Chorionic Gonadotropin: The
Role of the Carbohydrate Units,” Journal of Cellular Biochemistry, Suppl. 0, (11
Part A), p. 280, Abstract E233 (1987)
Bielinska, “Sulfation of the Choriogonadotropin Alpha Subunit in Human
Placental Explants,” Biochemical and Biophysical Research Communications ,
Vol. 148, No. 3, pp. 1446-1452 (1987)
Troalen et al. (Troalen), “Antigenic Determinants on Human Choriogonadotropin
I-Subunit,” Journal of Biological Chemistry, Vol. 263, No. 21, pp. 10370-10376
(1988)
Claims 14, 15, 47, and 49 stand rejected under 35 U.S.C. § 103 as
obvious over Matzuk (PNAS) in view of Fiddes, Troalen, Merz, Bielinska, and
Wallace.
Claims 14, 15, and 49 stand rejected under 35 U.S.C. § 103 as obvious
over Reddy, Fiddes, Troalen, Merz, Bielinska, and Wallace.
Claims 48, 50, and 52 stand rejected under 35 U.S.C. § 103 as obvious
over Matzuk (PNAS) in view of Fiddes, Troalen, Merz, Bielinska, and Wallace,
further in view of Matzuk (JCB), Morell, Gottleib, Parsons, and Clark.
Claims 47, 48, 50, and 52 stand rejected under 35 U.S.C. § 103 as
obvious over Reddy, Fiddes, Troalen, Merz, Bielinska, and Wallace, further in
view of Matzuk (JCB), Morell, Gottleib, Parsons, and Clark.
We reverse.
Background
Appellants’ specification discloses (pages 1-2) that human gonadotropin a
subunit combines with different ß subunits to form several different hormones,
including follicle-stimulating hormone, lutenizing hormone, and chorionic
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