Appeal No. 1997-3275
Application No. 07/963,329
incompletely known." (page 2407, first sentence of the abstract) (Emphasis added.).
Ocrant, further, notes that "[a]ffinity labeling disclosed differences in the apparent mol. wt.
of IGF-I and IGF-II receptors from bovine eye tissue and those from liver and brain."
(Abstract, col. 2). In stating his conclusion, Ocrant states "[w]e conclude that mammalian
retina contains both IGF-I and -II receptors, which differ from those found in other tissues
and have a characteristic spatial distribution within the retina." (Abstract, last sentence). At
page 2411, column 1, first full paragraph, Ocrant observes that "the retina expresses
unique forms of both type 1 and 2 receptors on the basis of apparent M in polyacrylamide
r
gels. . . . The meaning of these differences, in functional terms, is not understood." This
discussion, taken as a whole, would bring into question whether one of ordinary skill in this
art, noting the difference in the nature of the neurons located in different tissues of the
mammal, would reasonably expect the IGFs to act pharmacologically in the photoreceptors
of the mammal in the same manner as they would act on other neurons found at the other
sites within the mammal. This conclusion is reinforced by the concluding remarks of
Ocrant which state (page 2412, col. 1, last sentence of the first paragraph):
Since our data indicate that the mammalian retina contains
unique forms of both type 1 and 2 receptors, each of which
has a characteristic spatial distribution within the retina, these
studies imply that the retina may be valuable in identifying
potentially new and unique actions of IGFs in the CNS.
(Emphasis added.)
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