Ex parte BOZYCZKO-COYNE et al. - Page 13




               Appeal No. 1997-3275                                                                                               
               Application No. 07/963,329                                                                                         

                      The examiner has provided no facts or evidence which would reasonably establish                             
               that administration of IGF-1 to a mammal would have any particular pharmacological effect                          
               on the photoreceptors.  In our opinion, the references relied upon, taken in combination,                          
               would not have suggested to one of ordinary skill in this art at the time of the invention, that                   
               the administration of IGF-1 would have likely resulted in promoting the survival of                                
               photoreceptors as presently claimed.  Only appellants' specification provides any                                  
               suggestion that administering IGF-1 to a mammal would serve to promote the survival of                             
               photoreceptors at risk of dying.  However, use of this information as a basis for                                  
               establishing a prima facie case of obviousness, within the meaning of 35 U.S.C. § 103,                             
               would constitute impermissible hindsight.                                                                          
                      Thus, in our opinion, the examiner has failed to provide those facts or evidence                            
               which would reasonably support a conclusion that the claimed subject matter would have                             
               been prima facie obvious within the meaning of 35 U.S.C. § 103.   Where the examiner                               
               fails to establish a prima facie case, the rejection is improper and will be overturned.  In re                    
               Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598 (Fed. Cir.1988).  Therefore, this                                   
               rejection of claim 1 under 35 U.S.C. § 103 is reversed.                                                            
                      In rejecting the claims under the judicially created doctrine of obviousness-type                           
               double patenting, the examiner initially focuses on claim 1 of U.S. Patent 5,093,317 to                            
               Lewis and states that the patent is (Answer, page 10):                                                             



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