Ex parte CHENE et al. - Page 4



                       Appeal No.  1998-0365                                                                                                                     
                       Application No.  08/501,336                                                                                                               

                       the Doehner et al. reference, one skilled in the art would arrive at the instant claimed                                                  
                       compounds.”                                                                                                                               
                                 The initial burden of presenting a prima facie case of obviousness rests on                                                     
                       the examiner.  In re Oetiker, 977 F.2d 1443, 1445, 24 USPQ2d 1443, 1444  (Fed.                                                            
                       Cir. 1992).  As argued by appellants (Brief, page 8) “there is nothing in the                                                             
                       disclosure of Doehner et al suggesting that one should select the specific                                                                
                       substituents that are recited in the instant claims.”  As appellants argue (Brief, page                                                   
                       8) even Doehner’s preferred embodiments fail to lead one toward the claimed                                                               
                       invention.  Barnes fails to make up for the deficiency in Doehner.  However, even if                                                      
                       one were to select the specific substituents recited in the instant claims, the                                                           
                       examiner failed to identify in either of the references where a suggestion can be                                                         
                       found to order the substituents on the ring in the manner required by the claimed                                                         
                       invention.                                                                                                                                
                                 To establish a prima facie case of obviousness, there must be more than the                                                     
                       demonstrated existence of all of the components of the claimed subject matter.                                                            
                       There must be some reason, suggestion, or motivation found in the prior art                                                               
                       whereby a person of ordinary skill in the field of the invention would make the                                                           
                       substitutions required.  That knowledge cannot come from the applicants' disclosure                                                       
                       of the invention itself.   Diversitech Corp. v. Century Steps, Inc.,  850 F.2d 675,                                                       
                       678-79,  7 USPQ2d 1315, 1318 (Fed. Cir. 1988); In re Geiger, 815 F.2d 686, 688,                                                           
                       2 USPQ2d 1276, 1278 (Fed. Cir. 1987);  Interconnect Planning Corp. v. Feil, 774                                                           
                                                                                                                                                                 
                       35 U.S.C. § 112, fourth paragraph.                                                                                                        
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