Ex parte HUGHES et al. - Page 10




              Appeal No. 1998-0653                                                                         10                
              Application No. 08/282,278                                                                                     


              On the facts and arguments presented by the examiner in this case, the burden of proof                         

              is on the examiner to show that substituted lithium acetylide compounds cannot replace                         

              the unsubstituted hydrogen on the acetylide corresponding to R4 on the naphthopyran                            
              with a different moiety, or in the alternative, if a different moiety is placed on the lithium                 

              acetylide, it could not react to form the requisite naphthopyran compound of the claimed                       

              subject matter having a substituent other than hydrogen on the R4 position.  This burden                       
              of proof has not been met.  We find that the examiner’s statement, Answer, page 12, is                         

              merely speculative and does not rise to the requisite level of evidence required to                            

              establish a prima facie case of lack of lack of enablement.                                                    

                      Based upon the above findings and analysis the rejection by the examiner under                         

              35 U.S.C. § 112 is not sustained.                                                                              

              DECISION                                                                                                       

             The rejection of claims 1 through 7 and 41 under 35 U.S.C. § 112, first and                                     

             second paragraphs as the claimed invention is not described in such full, clear, concise,                       

             and exact terms to enable any person skilled in the art to make and use the same, and/or                        

             for failing to particularly point out and distinctly claim the subject matter which appellants                  

             regard as the invention is reversed.                                                                            

             The rejection of claims 1 through 7 under 35 U.S.C. § 112, second paragraph for                                 

             failing to particularly point out and distinctly claim the subject matter which appellants                      







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