Ex parte MISHIKAWA et al. - Page 9


                 Appeal No. 1998-1245                                                                                                             
                 Application No. 08/111,831                                                                                                       

                 suggest that improved brain function as described by Kimura II relates to the treatment of                                       
                 psychosis as claimed in claim 14.                                                                                                
                         The examiner has cited the two VanRollins abstracts, apparently, to establish that                                       
                 the metabolites of DHA utilized in claims 8 - 13 are known in the prior art. (Supp. Answer,                                      
                 pages 3 and 4).  However, these abstracts provide no information as to the possible use of                                       
                 these derivatives to obtain a pharmacological effect or to suggest that any of the                                               
                 derivatives would be useful in treating psychosis as presently claimed.  As we have stated                                       
                 above, merely because these compounds are metabolites of DHA does not, standing                                                  
                 alone, suggest their use in the manner presently claimed.  In fact, the only information to be                                   
                 found in this record which would suggest the use of the metabolites and or derivatives of                                        
                 DHA for the treatment of psychosis appears to be appellants' disclosure of the present                                           
                 invention.  However, use of this information as a basis for establishing a prima facie case                                      
                 of obviousness, within the meaning of 35 U.S.C. § 103, would constitute impermissible                                            
                 hindsight.                                                                                                                       
                         Thus, we conclude, that on this record, the examiner has failed to provide facts or                                      
                 substantive evidence which would reasonably support a conclusion that the claimed                                                
                 subject matter would have been obvious within the meaning of 35 U.S.C. § 103.  Where,                                            
                 as here, the examiner fails to establish a prima facie case, the rejection is improper and                                       
                 will be overturned.  In re Fine,  837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598 (Fed.                                                 
                 Cir.1988).  Therefore, we reverse the rejections of claims 8 - 14 under 35 U.S.C. § 103.                                         






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