Appeal No. 1998-1283
Application No. 08/449,731
Claims 19, 20, 52, 53, and 64 read as follows:
19. A method to aid in the diagnosis or prognosis of a neoplastic tissue of a
human, comprising:
detecting somatic alteration of wild-type APC protein in a tumor tissue isolated from
a human, said alteration indicating neoplasia of the tissue, wherein the alteration of wild-
type APC protein is detected by immunoblotting.
20. A method to aid in the diagnosis or prognosis of a neoplastic tissue of a
human, comprising:
detecting somatic alteration of wild-type APC protein in a tumor tissue isolated from
a human, said alteration indicating neoplasia of the tissue, wherein the alteration of wild-
type APC protein is detected by immunocytochemistry.
52. A method to aid in the detection of genetic predisposition to cancer,
including familial adenomatous polyposis (FAP) and Gardner’s Syndrome (GS), in a
human comprising:
detecting a germline alteration of wild-type APC protein in a human sample
selected from the group consisting of blood and fetal tissue, said alteration indicating
predisposition to cancer, wherein the alteration of wild-type APC is detected by
immunoblotting.
53. A method to aid in the detection of genetic predisposition to cancer,
including familial adenomatous polyposis (FAP) and Gardner’s Syndrome (GS), in a
human, comprising:
detecting a germline alteration of wild-type APC protein in a human sample
selected from the group consisting of blood and fetal tissue, said alteration indicating
predisposition to cancer, wherein the alteration of wild-type APC protein is detected by
immunocytochemistry.
64. A method to aid in the diagnosis or prognosis of a neoplastic tissue of a
human, comprising:
detecting somatic alteration of wild-type APC protein in a tumor tissue isolated from
a human, said alteration indicating neoplasia of the tissue.
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