Ex Parte D'ANTONIO - Page 15


                     Appeal No. 1998-1987                                                                                                       
                     Application No. 07/915,783                                                                                                 

                     then in a second step “adding a non-ionic detergent to the suspension.”  In                                                
                     Kilejian and Epstein, the non-ionic detergent (together with phosphate buffer and                                          
                     other components) is added to water and then this detergent solution is used to                                            
                     extract the plasmodial parasites.                                                                                          
                             This slight difference does not distinguish the claimed composition from                                           
                     those disclosed in the prior art.  The claims subject to the instant rejections are                                        
                     all directed to products, not processes.  “The patentability of a product does not                                         
                     depend on its method of production.  If the product in a product-by-process claim                                          
                     is the same as or obvious from a product of the prior art, the claim is                                                    
                     unpatentable even though the prior product was made by a different process.”  In                                           
                     re Thorpe, 777 F.2d 695, 697, 227 USPQ 964, 966 (Fed. Cir. 1985).  There is no                                             
                     evidence in the record that the same non-ionic detergent will solubilize different                                         
                     antigens from plasmodial parasites depending on whether it is present in the                                               
                     extraction buffer, rather than being added in a second step after the plasmodial                                           
                     parasites are suspended in water.  The prior art compositions thus reasonably                                              
                     appear to meet all of the limitations of claim 68.  The Kilejian and Epstein                                               
                     references therefore support a prima facie case of anticipation.                                                           
                             Appellant argues that both Kilejian and Epstein fail to teach the claimed                                          
                     compositions.  Appellant argues that the references are deficient because they                                             
                             “1)  Used a detergent to extract parasite antigens,                                                                
                             2)  None removed detergents from their extracts,                                                                   
                             3)  None showed that the extracted antigens were insoluble or                                                      
                                 would aggregate in insoluble form after detergent removal, and                                                 


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