Ex Parte D'ANTONIO - Page 18


                     Appeal No. 1998-1987                                                                                                       
                     Application No. 07/915,783                                                                                                 

                             “[W]hen the PTO shows sound basis for believing that the products of the                                           
                     applicant and the prior art are the same, the applicant has the burden of showing                                          
                     that they are not.”  In re Spada, 911 F.2d 705, 708, 15 USPQ2d 1655, 1658                                                  
                     (Fed. Cir. 1990).  Appellant has not shown that the prior art compositions fail to                                         
                     meet any of the limitations of claim 68.  We therefore affirm the rejections under                                         
                     35 U.S.C. § 102 based on Kilejian and Epstein.  Since we find that Kilejian and                                            
                     Epstein anticipate claim 68, we do not reach the alternative basis under 35                                                
                     U.S.C. § 103.  We also find it unnecessary to consider the disclosures of                                                  
                     Schmidt-Ullrich, Howard, and Newbold, which were relied on as alternatives to                                              
                     Kilejian or Epstein.                                                                                                       
                     5.  The § 103 rejection.                                                                                                   
                             The examiner rejected claims 84-88 and 90-100 as obvious in view of the                                            
                     disclosure of either Kilejian or Schmidt-Ullrich.  The examiner reasons that the                                           
                     references teach processes of obtaining plasmodial parasite antigens using non-                                            
                     ionic detergent, and that the process steps recited in the claims “appear to be                                            
                     conventional extraction steps and known to persons of skill in the art at the time                                         
                     the invention was made.”  Examiner’s Answer, pages 14-15.  Therefore, the                                                  
                     examiner concludes that the claimed process would have been obvious in view                                                
                     of the references.                                                                                                         
                             “It is well-established that before a conclusion of obviousness may be                                             
                     made based on a combination of references, there must have been a reason,                                                  
                     suggestion, or motivation to lead an inventor to combine those references.”  Pro-                                          
                     Mold and Tool Co. v. Great Lakes Plastics Inc., 75 F.3d 1568, 1573, 37 USPQ2d                                              

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