Ex parte VINOGRADOV et al. - Page 8


                  Appeal No.  1998-2107                                                                                        
                  Application No.  08/137,624                                                                                  
                  There must be some reason, suggestion, or motivation found in the prior art                                  
                  whereby a person of ordinary skill in the field of the invention would make the                              
                  substitutions required.  That knowledge cannot come  from the applicants'                                    
                  disclosure of the invention itself.   Diversitech Corp. v. Century Steps, Inc., 850 F.2d                     
                  675, 678-79, 7 USPQ2d 1315, 1318 (Fed. Cir. 1988); In re Geiger,                                             
                  815 F.2d 686, 688, 2 USPQ2d 1276, 1278 (Fed. Cir. 1987);  Interconnect Planning                              
                  Corp. v. Feil, 774 F.2d 1132, 1143,  227 USPQ 543, 551 (Fed. Cir. 1985).  On this                            
                  record we agree with appellants (Reply Brief8, page 12) “the Examiner instantly has                          

                  discussed no references containing any suggestion or motivation to use applicant’s                           
                  [sic] claimed starting materials to obtain the novel water soluble oxygen-quenchable                         
                  porphyrin compounds recited in the instant claims.”                                                          
                          Finally, we note that the examiner makes two references to Graham v. John                            
                  Deere Co., 383 U.S. 1, 148 USPQ 459 (1966) in his response (Answer, pages 9                                  
                  and 10) to the appellants’ arguments.  However, in applying a per se rule of                                 
                  obviousness the examiner ignored the principles set forth in Graham v. John Deere                            
                  Co.  We remind the examiner as set forth in the Manual of Patent                                             











                                                                                                                               
                  8 Paper No. 22, received November 19, 1997.                                                                  

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