Appeal No. 1998-2588
Application No. 08/673,702
APPENDIX I
1. A compound of
Formula I:
wherein
1
each of R and R is independently hydrogen, hydroxy, C -C -alkoxy,
1 4
benzyloxy, C -C -alkanoyloxy, benzoyloxy, substituted benzoyloxy bearing 1 to 3
1 6
substituents each of which is independently halo, C -C loweralkyl, or C -C1 4 1 4
-loweralkoxy, C alkoxycarbonyloxy, or C -C alkysulfonyloxy;1-5- 4 6 -
3
R is -CH=CH- (trans) or -CH2 -CH2-;
4 5 5
R is hydroxy, C - C alkoxy, or -N(R ) 2 wherein each R is taken separately1 4-
5
and independently represents hydrogen or C -C -alkyl, or both R are taken with the N
1 6
atom and constitute pyrrolidino, piperidino, hexamethyleneimino, or morpholino; or a
pharmaceutically acceptable salt thereof.
3
2. A compound of claim 1 wherein R is - CH=CH- (trans).
11. A method for alleviating a symptom of post-menopausal syndrome
comprising administering to a woman in need of such treatment an effective amount of a
compound of Claim 1.
8
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