Ex parte MANCILLA et al. - Page 2


                     Appeal No.  1999-1281                                                                                                      
                     Application No.  08/712,249                                                                                                


                             Claims 27 is illustrative of the subject matter on appeal and is reproduced                                        
                     below:                                                                                                                     
                             27. An anticoagulant composition which does not adversely affect the                                               
                                  measurement of calcium ion concentration within a blood sample                                                
                                  produced by a process comprising                                                                              
                                  (a) contacting an aqueous solution of sodium heparin with an acidic ion                                       
                                       exchange resin for a period of time sufficient such that the aqueous                                     
                                       effluent produce [sic] possesses a pH of about 3 or less;                                                
                                  (b) reacting said effluent with a heavy metal-containing compound                                             
                                       suitable to produce a heavy metal heparin salt;                                                          
                                  (c) reacting said heavy metal heparin salt produced in Step (b) with an                                       
                                       aqueous solution of lithium salts in sufficient amounts such that the                                    
                                       resulting solution exhibits a pH of about 6 to about 7.                                                  
                             The references relied upon by the examiner are                                                                     
                     Eisenhardt et al. (Eisenhardt)                     4,687,000                Aug. 18, 1987                                  
                     (Celsus) “Heparin-Blood Collection and Analysis,” Celsus Laboratories, Inc.,                                               
                     Cincinnati, Ohio (1991)                                                                                                    
                                                       GROUND OF REJECTION                                                                      
                             Claim 27-49 stand rejected under 35 U.S.C. § 103 as being unpatentable                                             
                     over Eisenhardt in view of Celsus.                                                                                         
                             We reverse.                                                                                                        
                                                               DISCUSSION                                                                       
                             In reaching our decision in this appeal, we have given careful consideration                                       
                     to the appellants’ specification and claims, and to the respective positions                                               
                     articulated by the appellants and the examiner.  We make reference to the                                                  
                     examiner’s Answer1 for the examiner’s reasoning in support of the rejections.  We                                          


                                                                                                                                                
                     1 Paper No. 24, mailed March 20, 1998.                                                                                     

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