Ex parte MANCILLA et al. - Page 6


                     Appeal No.  1999-1281                                                                                                      
                     Application No.  08/712,249                                                                                                

                             Therefore, we agree with appellants (Reply Brief, page 8) that “[n]o prima                                         
                     facie case has been made out and therefore the burden has not properly shifted to                                          
                     [a]ppellants to provide evidence of unexpected superior results.”                                                          
                             The initial burden of presenting a prima facie case of obviousness rests on                                        
                     the examiner.  In re Oetiker, 977 F.2d 1443, 1445, 24 USPQ2d 1443, 1444 (Fed.                                              
                     Cir. 1992).  In our opinion, since the examiner’s combination of references fail to                                        
                     teach a heparin molecule having more than one metal salt thereon, the examiner                                             
                     has not meet her burden of establishing a prima facie case of obviousness under                                            
                     35 U.S.C. § 103.                                                                                                           
                             Where the examiner fails to establish a prima facie case, the rejection is                                         
                     improper and will be overturned.  In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596,                                          
                     1598 (Fed. Cir. 1988).  Accordingly, we reverse the examiner’s rejection of claims                                         
                     27-49 under 35 U.S.C. § 103.                                                                                               
                             Having determined that the examiner has not established a prima facie case                                         
                     of obviousness, we find it unnecessary to discuss appellants evidence of                                                   
                     unexpected results relied on by appellants to rebut any such prima facie case.                                             

                                                                REVERSED                                                                        

                                                                                        )                                                       
                                              William F. Smith                         )                                                       
                                              Administrative Patent Judge               )                                                       
                                                                                        )                                                       
                                                                                        )                                                       
                                                                                        ) BOARD OF PATENT                                       
                                              Carol A. Spiegel                         )                                                       
                                              Administrative Patent Judge               )   APPEALS AND                                         


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