Ex Parte WOOD et al - Page 8


                  Appeal No. 1999-1730                                                                                           
                  Application No. 08/478,205                                                                                     

                  dissertation to be important.  Only with the benefit of hindsight can this passage                             
                  be read to suggest mutating other amino acids in the 223-247 region.                                           
                          We therefore agree with Appellants that the cited references would not                                 
                  have motivated a person of ordinary skill in the art to alter the amino acid                                   
                  sequence of P. plagiophthalamus luciferase at the positions recited in claim 1.                                
                  Since the references do not provide the requisite motivation to make the claimed                               
                  product, they do not support a prima facie case of obviousness.                                                
                                                           Summary                                                               
                          We reverse the rejection for obviousness because the cited reference do                                
                  not provide the requisite motivation to modify the known compound as required                                  
                  to meet the limitations of the claims.                                                                         


                                                         REVERSED                                                                




                                         Douglas W. Robinson                   )                                                 
                                         Administrative Patent Judge           )                                                 
                                                                               )                                                 
                                                                               )                                                 
                                                                               ) BOARD OF PATENT                                 
                                         Donald E. Adams                       )                                                 
                                         Administrative Patent Judge           )   APPEALS AND                                   
                                                                               )                                                 
                                                                               ) INTERFERENCES                                   
                                                                               )                                                 
                                         Eric Grimes                          )                                                 
                                         Administrative Patent Judge           )                                                 

                  EG/dym                                                                                                         

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