Ex Parte MILLER - Page 5


                 Appeal No.  2001-0120                                                           Page 5                   
                 Application No.  08/695,393                                                                              
                 (CCPA 1975).  The mere existence in the prior art of individual elements of                              
                 appellant’s invention does not, without more, render the claimed invention prima                         
                 facie obvious under 35 U.S.C. §103. Instead, there must be evidence that the                             
                 bringing together of such elements would have been prima facie obvious to a                              
                 person of ordinary skill in the art.                                                                     
                         Accordingly, we reverse the rejection of claims 1-9 under 35 U.S.C. § 103                        
                 as being unpatentable over Bockow.                                                                       
                 Cassuto in view of Partain:                                                                              
                         According to the examiner (Answer, page 4), “Cassuto teaches treating                            
                 burns by the topical application of a local anesthetic agent such as benzocaine,                         
                 procaine, or tetracaine at a concentration of 1.5% to 10%….”  The examiner                               
                 relies on Partain (Answer, page 5), to “teach that additives such as sodium lauryl                       
                 sulfate in topical compositions enhance percutaneous adsorption of the active                            
                 ingredient.”                                                                                             
                         In response to the examiner’s rejection, appellant argues (Brief, page 9),                       
                 “[t]here is no motivation taught in either Partain or Cassuto for adding sodium                          
                 lauryl sulfate to tetracaine to treat burns as taught by the present invention.”  We                     
                 are compelled to agree with appellant.                                                                   
                         Partain is directed to delivery systems comprised of certain                                     
                 aminopolysaccharides including chitosan derivatives and pharmaceutical or                                
                 therapeutic actives.  Col. 2, lines 29-34.  We recognize the examiner’s                                  
                 arguments at page 8 of the Answer, wherein the examiner points out that “the                             
                 permeability of most pharmaceuticals is poor due to the barrier properties of the                        
                 skin” and that “Partain teaches that percutaneous absorption of pharmaceuticals                          





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