Ex Parte RAGHUPATHI et al - Page 3

                       Appeal No. 2001-1025                                                                                 Page 3                             
                       Application No.  09/191,974                                                                                                             
                       the examiner’s reasoning in support of the rejection.  We further reference                                                             
                       appellants’ Brief3 for the appellants’ arguments in favor of patentability.                                                             
                       THE REJECTION UNDER 35 U.S.C. § 103:                                                                                                    
                                The examiner directs (Answer, page 3) our attention to Paper No. 104 for                                                       
                       the statement of the rejection.  According to the examiner (Final Rejection, page                                                       
                       3) “Hruby discloses topical compositions comprising alpha-MSH5 peptide                                                                  
                       analogs, wherein said peptide analogues are useful in stimulating melanocyte                                                            
                       production in adult humans so that darkening of the skin is achieved.”  The                                                             
                       examiner finds (id.) that Hadley “teach topical compositions comprising cyclic                                                          
                       peptide analogs of alpha-MSH, wherein said peptide analogs are useful in                                                                
                       achieving darkening of the skin.”  However, the examiner recognizes (id.) that                                                          
                       neither Hruby nor Hadley “disclose combining the skin darkening peptides with                                                           
                       additional skin darkening compounds such as those claimed … i.e. theophylline,                                                          
                       dihydroxy acetone and copper gluconate.”                                                                                                
                                To make up for the deficiencies of Hruby and Hadley, the examiner relies                                                       
                       on Takata and Hubaud.  According to the examiner (Final Rejection, page 3)                                                              
                       Takata discloses “self-tanning cosmetic compositions comprising dihydroxy                                                               
                       acetone and a polymer … [and Hubaud], which discloses skin tanning                                                                      





                                                                                                                                                               
                       3 Paper No. 16, received April 24, 2000.                                                                                                
                       4 Final Rejection, mailed October 25, 1999.                                                                                             
                       5 Also known as alpha-melanotropin or alphamelanocyte stimulating hormone, a tridecapeptide of                                          
                       the formula: Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2.   See Hruby column                                             
                       1.                                                                                                                                      




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