Ex Parte CARUSO - Page 6


                 Appeal No. 2001-1043                                                         Page 6                    
                 Application No. 08/734,738                                                                             

                                                 OTHER MATTERS                                                          
                        We note that the rejection of the composition claims on appeal was made                         
                 in the context of the use of the composition disclosed in the specification—the                        
                 treatment of urinary incontinence.  But the treatment of urinary incontinence is                       
                 intended use, and does not serve to limit the claimed compositions.                                    
                        The panel has discovered several references pertinent to the patentability                      
                 of the claimed compositions in a brief search of only the patent literature.  The                      
                 first reference is U.S. Patent No. 4,898,860, to Musacchio et al.  That reference                      
                 discloses that an agent such as atropine, one of the claimed anticholinergics, is                      
                 not a potent competitor of [3H]dextromethorphan binding.  See Musacchio,                               
                 column 13, line 67-column 14, line 3.  The competition study would read on the                         
                 composition of claim 24 because the composition is not limited to any particular                       
                 form, the competition study would require the atropine and the                                         
                 dextromethorphan to be present in the same solution, and the use of                                    
                 “comprising” allows the presence of other components in the composition.  The                          
                 second reference, U.S. Patent No. 4,316,888, to Nelson, specifically discloses a                       
                 pharmaceutical composition comprising dextromethorphan in combination with                             
                 an anticholinergic, such as atropine.  See, e.g., Column 1, line 61-column 2, line                     
                 6.                                                                                                     
                        Upon receipt of this application, the examiner may want to address the                          
                 patentability issues raised in this section, as well as searching for addressing the                   
                 composition per se, and not in the context of its intended use.                                        







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