Ex Parte KLEIN et al - Page 2


                 Appeal No. 2001-1587                                                                                    
                 Application No. 08/506,268                                                                              

                        26.     A method for detecting contamination of a surface by an analyte,                         
                                comprising:                                                                              
                                wiping the surface to be tested with a wiping surface;                                   
                                providing a capillary active, chromatographic test strip having a                        
                        planar surface and two ends, with an eluant application zone proximate                           
                        one end and a target zone proximate the other end, and being in fluid                            
                        communication therebetween; thereafter                                                           
                                                                                                                        
                                contacting the planar surface of the test strip in an area between                       
                        the eluant application zone and the target zone with the wiping surface                          
                        forming a site of contact;                                                                       
                                applying eluant onto the eluant application zone to cause the eluant                     
                        to move toward the target zone and past the site of contact while                                
                        maintaining contact of the planar surface in said area by the wiping                             
                        surface in order to take up analyte in the eluant and to move the analyte to                     
                        the target zone; and thereafter                                                                  
                                measuring in the target zone an immunological binding reaction to                        
                        detect the analyte.                                                                              
                        The examiner relies on the following references:                                                 
                 Baier et al. (Baier)                      5,118,609            Jun.   2, 1992                          
                 Giegel                                   5,250,412            Oct.    5, 1993                         
                 Fitzpatrick et al. (Fitzpatrick)           5,451,504            Sep. 19, 1995                           
                        Claims 2-26 stand rejected under 35 U.S.C. § 103 as obvious in view of                           
                 Fitzpatrick, Giegel, and Baier.                                                                         
                        We reverse.                                                                                      
                                                      Background                                                         
                        The specification discloses a method for testing a surface for the presence                      
                 of an analyte such as an illegal drug.  See, e.g., page 2.  In the disclosed                            
                 method, the surface to be tested is swabbed with a “wiping surface” that picks up                       
                 any drug residue that may be present.  The wiping surface is then contacted with                        


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