Ex Parte YOKOYAMA et al - Page 4


             Appeal No. 2001-1725                                                                                    
             Application 09/009,536                                                                                  
                    Further, Yang is said to teach a combination of Bifidobacterium strains in food                  
             producing methods, used alone or in combination with two or more lactic acid bacteria                   
             including specifically Lactobacillus species bulgaricus, acidophilus, and casei.  The                   
             combination of strains is said to be suggested for a variety of fermentation processes,                 
             including soy milk.  (Examiner’s Answer, page 3, lines 19-24).                                          
                    The Examiner thus concludes that it would have been obvious to one of ordinary                   
             skill in the art at the time the invention was made to have included the Yang                           
             combination of bacterium in the process of Matsuura as they are taught to be useful in                  
             fermenting processes. (Examiner’s Answer, page 4, lines 7-17).                                          
                    The Appellants, on the other hand, contend that no prima facie case of                           
             obviousness has been established “since the cited references fail to contain some                       
             teaching or suggestion to modify or combine the references” (Appeal Brief, page 11,                     
             lines 3-4) and that “the cited references in combination do not teach or suggest the                    
             invention as a whole, including all the limitations of the claims”  (Appeal Brief, page 12,             
             lines 13-14).                                                                                           
                    We address the motivation component of the prima facie case of obviousness                       
             first.  It is beyond dispute that to establish obviousness based on a combination of the                
             elements disclosed in the prior art, there must be some motivation, suggestion or                       
             teaching of the desirability of making the specific combination that was made by the                    
             applicants. See In re Dance, 160 F.3d 1339, 1343, 48 USPQ2d 1635, 1637 (Fed. Cir.                       
             1998); In re Gordon, 733 F.2d 900, 902, 221 USPQ 1125, 1127 (Fed. Cir. 1984). When                      
             obviousness is based on the modification of a prior art reference, there must be a                      
             showing of a suggestion or motivation to modify the teachings of that reference. See                    


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