Ex Parte LENTZ - Page 13


            Appeal No. 2001-2168                                                      
            Application No. 09/083,307                                                

            examiner therefore concludes that it would have been                      
            obvious to remove the TNF receptor 1 and receptor 2                       
            molecules in view of the known effect of these receptors on               
            the patient’s immune response.                                            
                 Appellant does not challenge the examiner’s position                 
            that it would have been obvious to remove the TNF receptor                
            1 and receptor 2 molecules for the reasons discussed above                
            and on page 7 of the answer.  Appellant also concedes that                
            Chen teaches the art that the TNF receptors suppress the                  
            patient’s ability to fight cancer (see page 9 of the main                 
            brief).  However, appellant is understood to argue in                     
            substance (see page 9 of the main brief) that Lentz lacks a               
            teaching of a filter having a cutoff of 120,000 daltons,                  
            with the result that the examiner’s proposed combination of               
            Lentz and Chen “is not the same as what appellant is                      
            claiming” (main brief, page 9).  This argument does not                   
            challenge the examiner’s position on obviousness as                       
            discussed supra.  We are therefore satisfied that the                     
            examiner has established a prima facie case of obviousness                
            with respect to the subject matter claim 7 in light of the                
            reasons discussed above as well as our findings regarding                 
            the Lentz patent.                                                         




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