Ex Parte ARTER et al - Page 3




             Appeal No. 2001-2337                                                                                     
             Application No. 07/493,442                                                                               


             The references relied on by the examiner are:                                                            
                    Matsumoto et al. (Matsumoto)              4,675,290            Jun. 23, 1987                      
                    Kawaguchi et al. (Kawaguchi)              4,820,649            Apr. 11, 1989                      
                    Batz et al. (Batz)                       4,845,030            Jul. 04,  1989                     
                    deCastro et al. (deCastro)                4,999,288            Mar. 12, 1991                      
             Hammond et al. (Hammond), “Development of an Enzyme-Based Assay for                                      
             Acetaminophen,”  Analytical Biochemistry,Vol.143 pp.152-157 (1984)                                       
             Arter et al. (Arter), “Development of a Multilayered Colorimetric Assay for Serum                        
             Acetaminophen,”  Clinical Chemistry, Vol. 39, No.6, p. 1230 (1993)                                       
                                             GROUND OF REJECTION                                                      
                    Claims 9 through 11, 14 and 17 stand rejected under 35 U.S.C. § 103.  As                          
             evidence of obviousness, the examiner relies on Arter, Hammond, Matsumoto,                               
             deCastro and Batz.                                                                                       
                    Claims 13, 15 and 16 stand rejected under 35 U.S.C. § 103.  As evidence of                        
             obviousness, the examiner relies on Arter, Hammond, Matsumoto, deCastro, Batz and                        
             Kawaguchi.                                                                                               
                    On consideration of the record, we reverse.                                                       
                                                  BACKGROUND                                                          
                    The present invention “relates to a spectrophotometric assay for the detection of                 
             acetaminophen in aqueous fluids which is carried out with a dry analytical element”                      
             (specification, page 1).  “An advantage of the invention is that the water-soluble                       
             coupling agent and either the enzyme catalyzed oxidative coupling or the ferricyanide                    
             coupling allow for a rapid reaction” (specification, page 4).                                            



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