The opinion in support of the decision being entered today was not written for publication and is not binding precedent of the Board. Paper No. 34 UNITED STATES PATENT AND TRADEMARK OFFICE __________ BEFORE THE BOARD OF PATENT APPEALS AND INTERFERENCES __________ Ex parte TSE WEN CHANG __________ Appeal No. 2001-2497 Application No. 08/855,744 __________ ON BRIEF __________ Before WILLIAM F. SMITH, SCHENER, and GRIMES, Administrative Patent Judges. GRIMES, Administrative Patent Judge. DECISION ON APPEAL This is a decision on appeal under 35 U.S.C. § 134 from the examiner’s final rejection of claims 1 and 3, all of the claims in the application. Claim 1 and 3 read as follows: 1. A method of enhancing delivery of a therapeutic agent selected from the group consisting of tumor necrosis factor and interleukin-1 to a solid tissue site, comprising: administering to a patient a conjugate consisting of two individual single chain VH-VL binding molecules which are conjugated with a hydrophilic peptide linker, one single chain binding molecule having specificity for a solid tissue antigen and the other for the therapeutic agent, and waiting until the conjugate concentration in thePage: 1 2 3 4 5 6 7 8 9 10 11 12 13 NextLast modified: November 3, 2007