Ex Parte AVERBACK - Page 6


              Appeal No. 1999-0494                                                                                       
              Application 08/482,768                                                                                     

              pharmaceutical to retard oxidation."  The record copy of the Merck Index is difficult to                   
              read due to the photocopy supplied by the examiner but it does not appear to use the                       
              word "pharmaceutical."                                                                                     
                     In any event, the examiner's statement of the rejection under 35 U.S.C. § 103(a)                    
              is fundamentally deficient in that it does not address the subject matter of the claims as                 
              a whole.  As seen from claim 13, the composition must be "capable of crossing the                          
              blood-brain barrier."  Nowhere in the Examiner's Answer does the examiner explain how                      
              any of the references relied upon teaches or suggests this aspect of the claimed subject                   
              matter.                                                                                                    
                     The examiner's rejection under 35 U.S.C. § 103(a) is reversed.                                      
                            NEW GROUND OF REJECTION UNDER 37 CFR § 1.196(b)                                              
                     Under the provisions of 37 CFR § 1.196(b), we make the following new ground of                      
              rejection.                                                                                                 
                     Claims 13-15 and 17-21 are rejected under 35 U.S.C. § 102(b).  As evidence of                       
              anticipation, we rely upon Johnson.                                                                        
              1.     Claims 13-15                                                                                        
                     For ease of explaining the facts and reasoning in support of the new ground of                      
              rejection, we will consider these three claims as a group.                                                 
                     In considering claims 13, 14 and 15 together, it is apparent that cromolyn sodium                   
              meets the functional requirements of both claims 13 and 14 in terms of inhibiting                          
              formation of amyloid fibrils as confirmed by the results of Example 2 of the present                       
              specification.                                                                                             



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