Appeal No. 1999-1337 Page 2
Application No. 08/393,232
(b) filtering the solution through a filter to remove the interfering
substance, said filter being characterized by a highly inert
and low-binding de-acetylated cellulose membrane capable
of removing proteins and peptides having molecular weights
in the range of about 5,000 to about 30,000; and
(c) after the interfering substance has been removed from the
digest solution, subjecting a portion of the digest solution to
analysis by immunoassay to detect the analyte if present.
The references relied upon by the examiner are:
Ogawa 3,873,682 Mar. 25, 1975
Kung et al. (Kung) 4,963,658 Oct. 16, 1990
Baumgartner (‘642) 5,324,642 Jun. 28, 1994
Baumgartner (‘703) 07/737,703 filing date Jul. 30, 1991
Kimmel et al. (Kimmel), “The properties of papain,” Advances in Enzymology,
Vol. 19, pp. 267-334 (1957)
Holmes, “Degradation of human hair by papain Part I: The pattern of
degradation,” Textile Research Journal, pp. 706-712 (1964)
Baumgartner et al. (Baumgartner), “Detection of drug use by RIA analysis of
hair,” Clinical Nuclear Medicine, Vol. 10, p. P4 (1985)
Biaglow et al. (Biaglow), “Factors influencing the oxidation of cysteamine and
other thiols: Implications for hyperthermic sensitization and radiation protection,”
Radiation Research, Vol. 100, pp. 298-312 (1984)
Offidani et al. (Offidani), “Drugs in hair: A new extraction procedure,” Forensic
Science International, Vol. 41, pp. 35-39 (1989)
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