Appeal No. 1999-1433
Application 08/453,852
Claims 1, 3, 5 and 11 are illustrative of the subject matter on appeal and read as
follows:
1. A method for enhancing a humoral or cellular immune response in an
animal comprising administering to the animal
(a) a non-tumor substance against which it is desired to raise the immune
response; and
(b) an adjuvant effective amount of tumor necrosis factor-alpha.
3. The method of claim 2 wherein the substance is administered in the form
of a conjugate with a microbial or viral polypeptide.
5. The method of claim 1 wherein the substance is native to the animal.
11. The method of claim 1 wherein the substance is an animal virus antigen.
The references relied upon by the examiner are:
Cohen et al. (Cohen) 4,709,011 Nov. 24, 1987
Riggs 4,812,554 Mar. 14, 1989
Shepard et al. (Shepard) 4,963,354 Oct. 16, 1990
Staruch et al. (Staruch), “The Adjuvanticity of Interleukin 1 In Vivo,” J. Immunology,
Vol. 130, pp. 2191-2194 (1983).
Beutler et al. (Beutler), “Passive Immunization Against Cachectin/Tumor Necrosis
Factor Protects Mice from Lethal Effect of Endotoxin,” Science, Vol. 229, pp. 869-871
(1985).
Kato et al. (Kato), “Comparative Studies on Adjuvanticity of Klebsiella O3
Lipopolysaccharide and Its Lipid A and Polysaccharide Fractions,” Immunology, Vol. 54,
pp. 317-324 (1985).
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