Appeal No. 2001-0490 Page 2
Application No. 08/524,206
The references relied upon by the examiner are:
Chu et al. (Chu ‘985) 5,683,985 Nov. 4, 1997
Chu et al. (Chu ‘522) WO 92/18522 Oct. 29, 1992
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Atherosclerosis Progression,” Circulation, Vol. 86, Suppl. III, pp. III-47-III-52
(1992)
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Milligan et al. (Milligan), “Current Concepts in Antisense Drug Design,” Journal of
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Stein et al. (Stein), “Antisense Oligonucleotides as Therapeutic Agents – Is the
Bullet Really Magical?” Science, Vol. 261, pp. 1004-1012 (1993)
Schwartz et al. (Schwartz), “Subspecialty Clinics: Cardiology – Coronary
Restenosis: Prospects for Solution and New Perspectives From a Porcine
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Rubin et al. (Rubin), “Atherosclerosis in mice: getting to the heart of a polygenic
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Barinaga, “Gene Therapy for Clogged Arteries Passes Test in Pigs,” Science,
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Tseng et al. (Tseng), “Antisense oligonucleotide technology in the development
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