Appeal No. 2001-1437
Application No. 08/764,145
Claim 1 is representative of the claims on appeal and reads as follows.
1. A formulation that elicits a desired response from cellular receptors and
prevents subsequent desensitization of said receptors comprising an agonist suitable
for eliciting said response in a first amount effective for binding to said receptors in both
a high and a low affinity state effective for obtaining said response mixed with an
inhibitor of said agonist specific to said receptors, said inhibitor in a second amount
sufficient to prevent desensitization of said receptor, said second amount being
Ki(KDLKDH/2)-½ of said first amount, where KDL and KDH are dissociation constants of said
agonist in low and high affinity states, respectively, and Ki is the dissociation constant of
said inhibitor.
The references relied upon by the examiner are:
Geoffroy, M. et al. (Geoffroy), “Reduction of Desensitization of a Glutamate Ionotropic
Receptor by Antagonists,” Molecular Pharmacology, Vol. 39, pp. 587-591 (1991)
Fernandes, L.B., et al. (Fernandes), “$-Adrenoceptor desensitization in guinea-pig
isolated trachea,” European Journal of Pharmacology, Vol. 15, pp. 135-145 (1988)
Grounds of Rejection
Claims 1-5 stand rejected under 35 U.S.C. § 102(b) as anticipated or in the
alternative under 35 U.S.C. § 103(a) as obvious in view of Geoffroy.
Claims 1-5 stand rejected under 35 U.S.C. § 102(b) as anticipated or in the
alternative under 35 U.S.C. § 103(a) as obvious over Fernandes.
We reverse these rejections.
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