Ex Parte BREAKEFIELD et al - Page 1




                           The opinion in support of the decision being entered today was not written                 
                                   for publication and is not binding precedent of the Board.                         
                                                                                      Paper No.  52                   
                        UNITED STATES PATENT AND TRADEMARK OFFICE                                                     
                                                    __________                                                        
                              BEFORE THE BOARD OF PATENT APPEALS                                                      
                                            AND INTERFERENCES                                                         
                                                    __________                                                        
                                       Ex parte XANDRA O. BREAKEFIELD,                                                
                                            and ROBERT L. MARTUZA                                                     
                                                    __________                                                        
                                               Appeal No. 2001-1686                                                   
                                            Application No. 08/363,998                                                
                                                    __________                                                        
                                            HEARD:  February 7, 2002                                                  
                                                    __________                                                        
                 Before WINTERS, WILLIAM F. SMITH, and GREEN, Administrative Patent                                   
                 Judges.                                                                                              
                 GREEN, Administrative Patent Judge.                                                                  

                                              DECISION ON APPEAL                                                      
                        This is a decision on appeal under 35 U.S.C. § 134 from the examiner’s                        
                 final rejection of claims 54, 55, 57, 59-61 and 72-77.  Claim 54 is representative                   
                 of the subject matter on appeal, and reads as follows:                                               
                        54. A method of expressing a gene sequence in a neuronal cell of the                          
                            central nervous system, said method comprising:                                           
                        directly administering into said neuronal cell a herpes simplex virus 1                       
                 (HSV-1) mutant as a vector for gene delivery, said HSV-1 mutant comprising:                          
                               (a) a deletion in an immediate early gene whereby said deletion in                     
                                   an immediate early gene is replaced by                                             






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