Appeal No. 2001-2521 Page 2
Application No. 08/738,464
essentially of a receptor species complementary to the analyte and which device
generates data relating to the mass change on the surface of the device arising
from contacting the device with the flowing liquid stream; and
(ii) a piezoelectric surface wave reference device comprising
a receptor layer having little or no affinity for the analyte and which generates
data as to the interference arising from contacting the device with the flowing
liquid stream;
(b) continuously obtaining data from both the sample and reference
devices; and
(c) continuously, and contemporaneously with step (a), determining
the presence, quantity, or both the presence and quantity of the analyte in the
liquid sample.
The examiner relies on the following references:
DeFord et al. (DeFord) 4,283,201 Aug. 11, 1981
Issachar 5,156,972 Oct. 20, 1992
Ghazarossian et al. (Ghazarossian) 5,180,828 Jan. 19, 1993
Ligler et al. (Ligler) 5,183,740 Feb. 02, 1993
Myerholtz et al. (Myerholtz) 5,306,644 Apr. 26, 1994
The claims stand rejected under 35 U.S.C. § 103 as obvious in view of the
prior art, as follows:
• Claims 1-14 in view of Issachar;
• Claims 1-7, 13, and 14 in view of Myerholtz and DeFord;
• Claims 8-12 in view of Myerholtz, DeFord, and Ghazarossian;
• Claims 1-7 and 13 in view of Myerholtz and Ligler; and
• Claims 8-12 in view of Myerholtz, Ligler, and Ghazarossian.
We reverse all of these rejections.
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