Ex Parte KESSEL et al - Page 5




              Appeal No. 2002-0439                                                                                       
              Application No. 09/391,384                                                                                 
                     We agree with appellants that the examiner has not provided an indication of                        
              sufficient motivation to combine the cited references to support a prima facie case of                     
              obviousness.   To begin, two criteria have evolved for determining whether prior art is                    
              analogous: (1) whether the art is from the same field of endeavor, regardless of the                       
              problem addressed, and (2) if the reference is not within the field of the inventor's                      
              endeavor, whether the reference still is reasonably pertinent to the particular problem                    
              with which the inventor is involved.  In re Clay, 966 F.2d 656, 658-59, 23 USPQ2d                          
              1058, 1060 (Fed. Cir. 1992).  See also In re Deminski, 796 F.2d 436, 442, 230 USPQ                         
              313, 315 (Fed. Cir. 1986); In re Wood, 599 F.2d 1032, 1036, 202 USPQ 171, 174                              
              (CCPA 1979).   In our view, the examiner has not properly established that Takahashi,                      
              dealing with wastewater treatment is analogous art to the claimed process for the                          
              preparation of creatine or creatine monohydrate.                                                           
                     Moreover, it is well-established that the conclusion that the claimed subject                       
              matter is prima facie obvious must be supported by a preponderance of evidence, as                         
              shown by some objective teaching in the prior art or by knowledge generally available to                   
              one of ordinary skill in the art that would have led that individual to combine the relevant               
              teachings of the references to arrive at the claimed invention.  See In re Fine, 837 F.2d                  
              1071, 1074, 5 USPQ2d 1596, 1598 (Fed. Cir. 1988);  In re Oetiker,  977 F.2d 1443,                          
              1445,  24 USPQ2d 1443, 1444 (Fed. Cir. 1992).  As set forth in In re Kotzab, 217 F.3d                      
              1365, 1369-70, 55 USPQ2d 1313, 1316 (Fed. Cir. 2000):                                                      



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