Appeal No. 2002-0616 Page 4
Application No. 08/693,052
virus infection, while the use of each adjuvant alone was ineffective. See id. at
6.
Stünkel is cited for teaching that the adjuvant glycosylamide N-2(deoxy-2-
L-leucylamino-β-D-glucopyranosyl)-N-octadecyldodecanomide acetate is known
in the art, and is more effective than Freund’s adjuvant and aluminum hydroxide.
See id.
Penney is cited that octadecyl tyrosine hydrochloride is an effective
organic adjuvant, and does not induce side effects such as granulomata as the
site of injection as does aluminum. Id.
Weismüller is cited for teaching tripalmitoyl-S-glyceryl-cyteinylserylserine
covalently linked to s synthetic virus peptide vaccine, producing “long-lasting high
protection against foot and mouth disease and serotype-specific virus-
neutralizing antibodies in guinea-pigs after a single administration.” Id.
Ramasamy is cited for teaching the linking of antigenic peptides to bovine
serum albumin in combination with Freund’s adjuvant or aluminum hydroxide to
elicit antibodies. See id. at 8.
The rejection concludes:
It would have been prima facie obvious to one skilled in the
art at the time the invention was made to generate an adjuvant
composition, an immunogenic composition, and a kit comprising a
mineral salt adjuvant, and an adjuvant selected from the group
consisting of a glycosylamide, an ester of an aromatic amino acid,
and a lipopeptide for the purpose of enhancing immunological
responses of vaccinees [sic] to various antigens. Gupta teaches
claimed adjuvants aluminum hydroxide, aluminum phosphate,
calcium phosphate, and stearyl tyrosine, and the use of such
adjuvants with antigens such as influenza hemagglutinin and
pertussis toxoid, and the use of combinations of adjuvants.
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