Ex Parte MAKOWSKI et al - Page 14


                 Appeal No.  2002-0796                                                        Page 14                    
                 Application No. 09/110,994                                                                              

                 case of obviousness.  In fact, the rejection does not even address the limitation                       
                 of the use of a library wherein the peptide or protein members of the library                           
                 comprise an equal distribution of possible peptide sequences.  Therefore, the                           
                 rejection as it applies to the claims of Group III, i.e., claims 7-9, is reversed.                      
                        With respect to the claims of Group IV, Appellants argue that Petrenko                           
                 only employed biopanning in order to select high affinity binding members, and                          
                 the combination does not teach or suggest the use of alternating selection                              
                 methods.  Again, we agree that the examiner has not set forth a prima facie case                        
                 of obviousness, as, again, the rejection does not even address the limitation of                        
                 the use of alternating selection methods.  Therefore the rejection is also reversed                     
                 as to the claims of Group IV, i.e., claims 14 and 15.                                                   


























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