Appeal No. 2002-1296 Page 2
Application No. 08/957,038
(c) comparing the measured amount of active TGF-$1 produced in step (b)
with a control, the control being the measured amount of active TGF-$1
produced by the incubation of step (a) without the modulator compound of
step (a) in order to identify the modulator compound's propensity for scar
formation.
The references relied upon by the examiner are:
Purchio et al. (Purchio) 5,844,085 Dec. 1, 1998
Twardzik et al. (Twardzik), "(-Interferon-Induced Activation of Latent Transforming
Growth Factor-$ by Human Monocytes," Annals New York Academy of Sciences,
Vol. 593, pp. 276-84 (1990)
ATCC Cell Lines & Hybridomas, Eighth Ed., American Type Culture Collection, ISBN:
0930009541, p. 337 (eds. Hay et al., 1994)
Adams, "Macrophages," Cell Culture, Vol. 58, Chapter 43, pp. 494-506 (eds. Jacoby et
al., Academic Press, March 1979)
Huber, et al. (Huber), "Activation of Human Platelet-Derived Latent Transforming
Growth Factor-$1 by Human Glioblastoma Cells," Biochem. J., Vol. 277, pp. 165-177
(July 1, 1991)
Flaumenhaft et al. (Flaumenhaft), "Activation of Latent Transforming Growth Factor $,"
Adv. Pharmacol., Vol. 24, pp. 51-76 (1993)
Beauchamp et al. (Beauchamp), "Phenotypic Alterations in Fibroblasts and
Fibrosarcoma Cells that Overexpress Latent Transforming Growth Factor-$1,"
Endocrinology, Vol. 130, No. 5, pp. 2476-86 (1992)
Nunes et al. (Nunes), "Characterization of Latent TGF-$ Activation by Murine Peritoneal
Macrophages," J. Immunol., Vol. 155, No. 3, pp. 1450-59 (August 1, 1995)
Claims 15 through 21 stand rejected under 35 U.S.C. § 103(a). As evidence of
obviousness, the examiner relies upon various combinations of the references listed
above. We reverse.
Background
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