Ex Parte OSBORNE et al - Page 3



             Appeal No. 2002-1682                                                               Page 3                
             Application No. 09/023,696                                                                               
             references.                                                                                              
                    On consideration of the record, including the above-listed materials, we reverse                  
             the examiner's prior art rejection.                                                                      


                                                     Discussion                                                       
                    The examiner argues that Klaveness expressly discloses each and every                             
             element of the claimed invention.  We disagree.  The examiner does not point to any                      
             passage in Klaveness describing "an ultrasound contrast agent comprising hollow                          
             microcapsules characterized in that the microcapsules, when suspended in degassed                        
             water at 20°C to give a homogenous microcapsule concentration of 13.0 µg/ml, have a                      
             reflectivity to 3.5 MHz ultrasound of at least -1.0 dB" (claim 21, emphasis added) or "an                
             ultrasound contrast agent comprising hollow microcapsules characterized in that the                      
             microcapsules, when suspended in degassed water at 20°C to give a homogenous                             
             microcapsule concentration of 13.0 µg/ml, have a reflectivity to 3.5 MHz ultrasound of at                
             least  -7.4 dB" (claim 25, emphasis added).  Nor do we find any such disclosure in the                   
             Klaveness patent.  As stated by applicants, the claim limitation which specifies                         
             reflectivity in degassed water "defines a more rigorous test than is disclosed in                        
             Klaveness" (Paper No. 21, page 13).                                                                      
                    Additionally, the examiner argues that Erbel, Sutton, Schutt, Grinstaff, or                       
             Klaveness discloses microcapsules which "appear to be prepared by a process which is                     
             the same" as the process described in applicants' specification for preparing the                        
             claimed ultrasound contrast agent comprising hollow microcapsules (Paper No. 22,                         
             page 5).  According to the examiner, the prior art microcapsules must necessarily and                    





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