Appeal No. 2002-1874 Page 2
Application No. 09/079,329
47. A method of blocking toxic carbonyl containing compounds and/or
dicarbonyl containing compounds in a subject suffering from a condition
associated with carbonyl containing compounds and/or dicarbonyl
containing compounds by treating blood and/or blood products in a
dialysis system for return to the subject comprising administering in the
dialysis system a therapeutically effective dose to the subject’s blood
and/or blood products of a blocking agent selected from the group
consisting of arginine, substituted arginine, or modified arginine.
237. A method of blocking toxic carbonyl containing compounds and/or
dicarbonyl containing compounds in a subject suffering from a condition
associated with carbonyl containing compounds and/or dicarbonyl
containing compounds by treating blood and/or blood products in a
dialysis system for return to the subject comprising administering in the
dialysis system a therapeutically effective dose of D-arginine to the
subject’s blood and/or blood products.
The examiner relies upon the following references:
Lo et al. (Lo) “Binding and Modification of Proteins by Methylglyoxal under
Physiological Conditions,” The Journal of Biological Chemistry, Vol. 269, No.51,
pp. 32299-32305 (1994)
Khaidar et al. (Khaidar) “L-Arginine Reduces Heart Collagen Accumulation in the
Diabetic db/db Mouse,” Circulation, Vol. 90, pp. 479-483 (1979)
Selwood et al. (Selwood) “Binding of Methylglyoxal to Albumin and Formation of
Fluorescent Adducts, Inhibition by Arginine, Na Acetylarginine and
Aminoguanidine,” Biochemical Society Transactions, Vol. 21, AN 489354
p. 170S pp. 32299-32305 (1994)
Claims 47-49, 54-57 and 237-240 stand rejected under 35 U.S.C. § 112,
first paragraph, on the grounds that the specification does not enable any person
skilled in the art to which it pertains, or with which it is most nearly connected, to
make and/or use the invention commensurate in scope with the claims. Claims
47-49, 54-57 and 237-240 stand rejected under 35 U.S.C. § 112, second
paragraph, as being indefinite for failing to particularly point out and distinctly
1 In Paper No. 7, appellants elected D-arginine as the species to be examined.
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