Appeal No. 2002-2284 Page 2
Application No. 09/176,492
b) infecting the cells with at least one strain of rotavirus, and
c) harvesting the rotavirus.
The references relied upon by the examiner are:
Almeida 4,205,131 May 27, 1980
Bettger et al. (Bettger), “Rapid clonal growth and serial passage of human diploid
fibroblasts in a lipid-enriched synthetic medium supplemented with epidermal
growth factor, insulin, and dexamethasone,” Proc. Natl. Acad. Sci. USA, Vol. 78,
No. 9, pp. 5588-92 (1981)
Taub et al. (Taub), “The development of serum-free hormone-supplemented
media for primary kidney cultures and their use in examining renal functions,”
Ann. New York Academy of Science, pp. 406-21 (1981)
Zhaolie et al. (Zhaolie), “A novel serum-free medium for the cultivation of Vero
cells on microcarriers,” Biotechnology Techniques, Vol. 10, No. 6, pp. 449-52
(1996)
GROUNDS OF REJECTION
Claims 1 and 3 stand rejected under 35 U.S.C. § 103 as obvious over
Taub in view of Bettger.
Claim 3 stands rejected under 35 U.S.C. § 103 as obvious over Almeida
in view of Taub, Bettger, and Zhaolie.
We reverse.
DISCUSSION
Taub in view of Bettger:
According to the examiner (Answer, bridging paragraph, page 3-4), Taub
teach the “development of a serum-free medium for growth of kidney cell lines.
The medium (Medium K-1) is … designed for the growth of kidney cell cultures in
general. Taub discloses the optimization of growth factors and hormones … but
does not disclose addition of rhEGF or dexamethasone to Medium K-1….” To
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