Ex Parte SENDEROFF et al - Page 6


                 Appeal No.  2003-0338                                                       Page 6                   
                 Application No.  08/486,451                                                                          

                        This rejection suffers from the same deficiencies as the rejection over the                   
                 combination of Prestrelski and Manning.  With respect to claim 21, Igari I and                       
                 Igari II also teach a broad genus of protein compositions, with nothing directing                    
                 the ordinary artisan to the combination of thrombopoeitin with histidine.  With                      
                 respect to claim 24, again, the rejection does not even discuss the limitations of                   
                 that claim.  Thus, this rejection is reversed for the same reasons set forth above                   
                 with respect to the combination of Prestrelski and Manning.                                          

































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